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KMID : 1036720150480040310
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Journal of Nutrition and Health
2015 Volume.48 No. 4 p.310 ~ p.318
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Effects of natural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats
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Sim Boo-Yong
Bak Ji-Won
Lee Hae-Jin
Jun Ji-Ae
Choi Hak-Joo
Kwon Chang-Ju
Kim Hwa-Young
Ruff Kevin J.
Brandt Karsten
Kim Dong-Hee
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Abstract
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Purpose: The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM).
Methods: NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-1β, and IL-6 were measured by Luminex and PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system.
Results: Production of NO, IL-1β, IL-6, PGE2, MMP-2, MMP-9, TIMP-1, LTB4, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue.
Conclusion: The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.
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KEYWORD
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osteoarthritis, anti-Inflammatory, NEM, MIA, health food
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